[CAS NO. 13005-09-9] Dehydrocorydaline nitrate

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PRODUCTS SPECIFICATIONS [13005-09-9]

Catalog

HY-N4238

Brand

MCE

CAS

13005-09-9

DESCRIPTION [13005-09-9]

Overview

MDL	-
Molecular Weight	428.44
Molecular Formula	C22H24N2O7
SMILES	[O-][N+]([O-])=O.CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3

For research use only. We do not sell to patients.

18 Publications Citing Use of MCE

Summary

Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax , Bcl-2 ; activates caspase-7 , caspase-8 , and inactivates PARP ^[1] . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. ^[2] . Dehydrocorydaline nitrate shows strong anti-malarial effects ( IC ₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain ^[3] .

IC50 & Target

IC50: 38 nM ( P. falciparum 3D7 strain) ^[3]

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 116.70 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3340 mL	11.6702 mL	23.3405 mL
5 mM	0.4668 mL	2.3340 mL	4.6681 mL
10 mM	0.2334 mL	1.1670 mL	2.3340 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.84 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.84 mM); Clear solution

* All of the co-solvents are available by MCE.