[CAS NO. 1309793-47-2] (±)-CPSI-1306

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1309793-47-2]

Catalog

HY-110095

Brand

MCE

CAS

1309793-47-2

DESCRIPTION [1309793-47-2]

Overview

MDL	MFCD26792562
Molecular Weight	310.30
Molecular Formula	C15H16F2N2O3
SMILES	FC1=C(C=CC(F)=C1)C2=NOC(CC(N3CCOCC3)=O)C2

For research use only. We do not sell to patients.

Summary

(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF) .

IC50 & Target

MIF ^[1] .

In Vivo

Mice treated with CPSI-1306 show a significant drop in their blood glucose levels, which is associated with a reduction in serum levels of inflammatory cytokines. As expected, control mice treated with vehicle develop NIDDM as characterized by high serum levels of glucose and inflammatory cytokine. Furthermore, they also show that orally bioavailable CPSI-1306 can be effective in treating this disease ^[1] . CPSI-1306-induced keratinocyte apoptosis could be appreciated as early as 30 minutes after a single UVB exposure. At 6, 24, and 48 hours following UVB exposure, the CPSI-1306-treated mice show significantly increased expression of cleaved caspase-3 compared with the vehicle-treated mice. CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 6 mg/mL ( 19.34 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2227 mL	16.1134 mL	32.2269 mL
5 mM	0.6445 mL	3.2227 mL	6.4454 mL
10 mM	0.3223 mL	1.6113 mL	3.2227 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.6 mg/mL (1.93 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.6 mg/mL (1.93 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.6 mg/mL (1.93 mM); Clear solution

* All of the co-solvents are available by MCE.