[CAS NO. 1310744-67-2] PFM39
PRODUCTS SPECIFICATIONS [1310744-67-2]
DESCRIPTION [1310744-67-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 219.26 |
| Molecular Formula | C10H9N3OS |
| SMILES | O=C1N=C(N)S/C1=C\C2=CC=C(N)C=C2 |
Summary
PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity [1] .
In Vitro
PFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR)
[1]
.
PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 456.08 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.5608 mL | 22.8040 mL | 45.6080 mL |
| 5 mM | 0.9122 mL | 4.5608 mL | 9.1216 mL |
| 10 mM | 0.4561 mL | 2.2804 mL | 4.5608 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (11.40 mM); Clear solution