[CAS NO. 132489-69-1] (Z)-PUGNAc

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PRODUCTS SPECIFICATIONS [132489-69-1]

Catalog

HY-108241

Brand

MCE

CAS

132489-69-1

MDL	MFCD00145022
Molecular Weight	353.33
Molecular Formula	C15H19N3O7
SMILES	O=C(NC1=CC=CC=C1)O/N=C2[C@@H]([C@H]([C@@H]([C@H](O/2)CO)O)O)NC(C)=O

For research use only. We do not sell to patients.

(Z)-PUGNAc is a potent O-GlcNAcase inhibitor. (Z)-PUGNAc is a vastly more potent inhibitor of O-GlcNAcase than the E form ^[1] .

(Z)-PUGNAc amplifies the incorporation of O-GlcNAc on proteins within both HeLa and HEK cell systems ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 50 mg/mL ( 141.51 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.25 mg/mL (3.54 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.25 mg/mL (3.54 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (3.54 mM); Clear solution

* All of the co-solvents are available by MCE.

D-Gluconimidic acid, 2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-, δ-lactone, (1Z)-