[CAS NO. 1338824-20-6] NCGC00229600

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1338824-20-6]

Catalog

HY-18286

Brand

MCE

CAS

1338824-20-6

DESCRIPTION [1338824-20-6]

Overview

MDL	-
Molecular Weight	479.57
Molecular Formula	C30H29N3O3
SMILES	O=C1N(CC2=CC=CN=C2)C(C3=CC=C(OC)C(COC4=C(C)C=CC=C4C)=C3)NC5=C1C=CC=C5

For research use only. We do not sell to patients.

Summary

NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR) . NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves' disease ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 104.26 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0852 mL	10.4260 mL	20.8520 mL
5 mM	0.4170 mL	2.0852 mL	4.1704 mL
10 mM	0.2085 mL	1.0426 mL	2.0852 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.21 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.21 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Neumann S, et al. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54.