[CAS NO. 134234-12-1] Traxoprodil

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PRODUCTS SPECIFICATIONS [134234-12-1]

Catalog

HY-W018061

Brand

MCE

CAS

134234-12-1

DESCRIPTION [134234-12-1]

Overview

MDL	MFCD00926469
Molecular Weight	327.42
Molecular Formula	C20H25NO3
SMILES	OC1(C2=CC=CC=C2)CCN([C@@H](C)[C@@H](O)C3=CC=C(O)C=C3)CC1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]J Biochem. 2021 Dec 15;mvab140.

Summary

Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC ₅₀ of 10 nM.

IC50 & Target

IC50: 10 nM (Neuroprotection) ^[1]

In Vivo

Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED ₅₀ less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice ^[1] . Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the Forced swim test and it is not related to changes in animals’ locomotor activity ^[2] . Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures, and decreases the total time spent in seizures ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00163085	Pfizer	Parkinson´s Disease	May 2005	Phase 2
NCT00163059	Pfizer	Depressive Disorder, Major	May 2004	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL ( 190.89 mM ; Need ultrasonic)

H ₂ O : 0.1 mg/mL ( 0.31 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0542 mL	15.2709 mL	30.5418 mL
5 mM	0.6108 mL	3.0542 mL	6.1084 mL
10 mM	0.3054 mL	1.5271 mL	3.0542 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.35 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.35 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1-Piperidineethanol, 4-hydroxy-α-(4-hydroxyphenyl)-β-methyl-4-phenyl-, (αS,βS)-

1-Piperidineethanol, 4-hydroxy-α-(4-hydroxyphenyl)-β-methyl-4-phenyl-, [S-(R*,R*)]-

(αS,βS)-4-Hydroxy-α-(4-hydroxyphenyl)-β-methyl-4-phenyl-1-piperidineethanol

(+)-CP 101606

CP 101606

CP 98113

Traxoprodil

1-Piperidineethanol 4-hydroxy-α-(4-hydroxyphenyl)-β-methyl-4-phenyl-, (αS,βS)-