[CAS NO. 134418-28-3] Dehydroandrographolide

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PRODUCTS SPECIFICATIONS [134418-28-3]

Catalog

HY-N0676

Brand

MCE

CAS

134418-28-3

DESCRIPTION [134418-28-3]

Overview

MDL	MFCD03093712
Molecular Weight	332.43
Molecular Formula	C20H28O4
SMILES	C[C@@]([C@H]1C/C=C(C=CO2)/C2=O)(CC[C@H]3O)[C@@](CCC1=C)([H])[C@]3(C)CO

For research use only. We do not sell to patients.

Summary

Dehydroandrographolide can be extracted from herbal medicine Andrographis paniculata Nees . Dehydroandrographolide reduces oxidative stress in LPS-induced acute lung injury by inactivating iNOS . Dehydroandrographolide has anti-infective activity ^[1] ^[2] ^[3] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 752.04 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0082 mL	15.0408 mL	30.0815 mL
5 mM	0.6016 mL	3.0082 mL	6.0163 mL
10 mM	0.3008 mL	1.5041 mL	3.0082 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2(3H)-Furanone, 3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, (3E)-

2(3H)-Furanone, 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, [1R-[1α,2α,4aα,5β(E),8aβ]]-

(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone

Dehydroandrographolide