[CAS NO. 1345853-49-7] Dynamin IN-2

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PRODUCTS SPECIFICATIONS [1345853-49-7]

Catalog

HY-152216

Brand

MCE

CAS

1345853-49-7

DESCRIPTION [1345853-49-7]

Overview

MDL	-
Molecular Weight	364.87
Molecular Formula	C22H21ClN2O
SMILES	ClC(C=C1)=CC=C1CNCC(CN2C3=CC=CC=C3C4=CC=CC=C42)O

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Summary

Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC ₅₀ of 1.0 μM for dynamin I GTPase . Dynamin IN-2 also blocks clathrin mediated endocytosis ( CME ), with an IC ₅₀ of 9.5 μM ^[1] .

IC50 & Target

IC ₅₀ : 1.0 ± 0.2 μM (dyn I GTPase), 9.5 ± 2.5 μM (CME) ^[1]

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Cossar PJ, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.