[CAS NO. 13463-41-7] Zinc Pyrithione
PRODUCTS SPECIFICATIONS [13463-41-7]
DESCRIPTION [13463-41-7]
Overview
| MDL | MFCD00067336 |
|---|---|
| Molecular Weight | 317.69 |
| Molecular Formula | C10H8N2O2S2Zn |
| SMILES | N12[O-][Zn+2]3([S]=C1C=CC=C2)[O-]N(C=CC=C4)C4=[S]3 |
4 Publications Citing Use of MCE
Summary
Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump [1] . Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis [2] .
In Vitro
Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn
2+
via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K
1/2
) of about 0.3 mM
[1]
.
Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 104.91 mM ; Need ultrasonic)
H 2 O : 0.1 mg/mL ( 0.31 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1477 mL | 15.7386 mL | 31.4772 mL |
| 5 mM | 0.6295 mL | 3.1477 mL | 6.2954 mL |
| 10 mM | 0.3148 mL | 1.5739 mL | 3.1477 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution
References
Synonyms