[CAS NO. 1354790-56-9] DMT1blocker1

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PRODUCTS SPECIFICATIONS [1354790-56-9]

Catalog

HY-126301

Brand

MCE

CAS

1354790-56-9

DESCRIPTION [1354790-56-9]

Overview

MDL	-
Molecular Weight	294.31
Molecular Formula	C16H14N4O2
SMILES	OC1=C(C(NC2=CC=CC=C2)=O)C(C)=NN1C3=NC=CC=C3

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]J Neuroinflammation. 2020 Apr 11;17(1):110.

Summary

DMT1 blocker 1 (compound 6f) is a blocker of divalent metal transporter 1 ( DMT1 ) with an IC ₅₀ of 0.64 μM, is expected to block iron uptake by enterocytes in vivo ^[1] .

IC50 & Target

IC50: 0.64 μM (DMT1 blocker 1) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 169.89 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3978 mL	16.9889 mL	33.9778 mL
5 mM	0.6796 mL	3.3978 mL	6.7956 mL
10 mM	0.3398 mL	1.6989 mL	3.3978 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.83 mg/mL (2.82 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.83 mg/mL (2.82 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.83 mg/mL (2.82 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5.