[CAS NO. 1359164-11-6] SR2211
PRODUCTS SPECIFICATIONS [1359164-11-6]
DESCRIPTION [1359164-11-6]
Overview
| MDL | MFCD25563263 |
|---|---|
| Molecular Weight | 527.48 |
| Molecular Formula | C26H24F7N3O |
| SMILES | FC1=C(C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2)C=CC(C(C(F)(F)F)(O)C(F)(F)F)=C1 |
Summary
SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a K i of 105 nM and an IC 50 of ~320 nM.
In Vitro
The treatment of EL4 with SR2211 represses the IL-17 gene expression. Similarly, the expression of IL-23 receptor (Il23r) is significantly inhibited by SR2211. Treatment of EL-4 cells with SR2211 results in significant inhibition of IL-17 intracellular staining as compared to vehicle treated cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 189.58 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8958 mL | 9.4790 mL | 18.9581 mL |
| 5 mM | 0.3792 mL | 1.8958 mL | 3.7916 mL |
| 10 mM | 0.1896 mL | 0.9479 mL | 1.8958 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.74 mM); Clear solution
References
- [1] Kumar N, et al. Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem Biol. 2012 Apr 20;7(4):672-7.
- [2] Song Y, et al. Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. Eur J Med Chem. 2016 Jun 30;116:13-26.