[CAS NO. 1359944-60-7] MRT-83hydrochloride

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PRODUCTS SPECIFICATIONS [1359944-60-7]

Catalog

HY-18287A

Brand

MCE

CAS

1359944-60-7

DESCRIPTION [1359944-60-7]

Overview

MDL	-
Molecular Weight	575.05
Molecular Formula	C31H31ClN4O5
SMILES	O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC(NC(NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)=N)=CC=C3C.Cl

For research use only. We do not sell to patients.

Summary

MRT-83 (hydrochloride) is the potent antagonist of Smoothened ( Smo ) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo . MRT-83 (hydrochloride) has the potential for researching cancer disease ^[1] .

IC50 & Target

Smo ^[1]

In Vitro

MRT-83 (hydrochloride) (compound 86) has IC ₅₀ s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 434.74 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7390 mL	8.6949 mL	17.3898 mL
5 mM	0.3478 mL	1.7390 mL	3.4780 mL
10 mM	0.1739 mL	0.8695 mL	1.7390 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (3.62 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (3.62 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.62 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571.