[CAS NO. 1364488-67-4] YH239-EE
PRODUCTS SPECIFICATIONS [1364488-67-4]
DESCRIPTION [1364488-67-4]
Overview
| MDL | MFCD28099816 |
|---|---|
| Molecular Weight | 504.41 |
| Molecular Formula | C25H27Cl2N3O4 |
| SMILES | O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC |
Summary
YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent. IC50 value: Target: MDM2/p53 YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 55 mg/mL ( 109.04 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9825 mL | 9.9126 mL | 19.8251 mL |
| 5 mM | 0.3965 mL | 1.9825 mL | 3.9650 mL |
| 10 mM | 0.1983 mL | 0.9913 mL | 1.9825 mL |