[CAS NO. 136834-22-5] DMT-2'fluoro-da(bz)amidite
PRODUCTS SPECIFICATIONS [136834-22-5]
DESCRIPTION [136834-22-5]
Overview
| MDL | MFCD12912392 |
|---|---|
| Molecular Weight | 875.92 |
| Molecular Formula | C47H51FN7O7P |
| SMILES | COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N5C6=NC=NC(NC(C7=CC=CC=C7)=O)=C6N=C5)O4 |
Summary
Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 114.17 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.1417 mL | 5.7083 mL | 11.4166 mL |
| 5 mM | 0.2283 mL | 1.1417 mL | 2.2833 mL |
| 10 mM | 0.1142 mL | 0.5708 mL | 1.1417 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (2.85 mM); Clear solution