[CAS NO. 1373625-34-3] ARN077

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PRODUCTS SPECIFICATIONS [1373625-34-3]

Catalog

HY-120813

Brand

MCE

CAS

1373625-34-3

DESCRIPTION [1373625-34-3]

Overview

MDL	-
Molecular Weight	291.34
Molecular Formula	C16H21NO4
SMILES	O=C(OCCCCCC1=CC=CC=C1)N[C@@H]2[C@H](C)OC2=O

For research use only. We do not sell to patients.

Summary

ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC ₅₀ of 7 nM for human NAAA ^[1] . ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats ^[2] .

IC50 & Target

IC50: 7 nM (human NAAA) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 858.10 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4324 mL	17.1621 mL	34.3242 mL
5 mM	0.6865 mL	3.4324 mL	6.8648 mL
10 mM	0.3432 mL	1.7162 mL	3.4324 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.14 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.14 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.14 mM); Clear solution

* All of the co-solvents are available by MCE.