[CAS NO. 137553-43-6] DHFR-IN-3

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PRODUCTS SPECIFICATIONS [137553-43-6]

Catalog

HY-W003561

Brand

MCE

CAS

137553-43-6

DESCRIPTION [137553-43-6]

Overview

MDL	MFCD08706214
Molecular Weight	239.07
Molecular Formula	C8H7BrN4
SMILES	NC1=NC(N)=C2C=CC(Br)=CC2=N1

For research use only. We do not sell to patients.

Summary

DHFR-IN-3 is a dihydrofolate reductase ( DHFR ) inhibitor with the IC ₅₀ values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 418.29 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1829 mL	20.9144 mL	41.8288 mL
5 mM	0.8366 mL	4.1829 mL	8.3658 mL
10 mM	0.4183 mL	2.0914 mL	4.1829 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.46 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.46 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.46 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] A Rosowsky, et al. Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. Antimicrob Agents Chemother. 1995 Jan;39(1):79-86.