[CAS NO. 1381291-36-6] USP7-IN-1

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PRODUCTS SPECIFICATIONS [1381291-36-6]

Catalog

HY-16709

Brand

MCE

CAS

1381291-36-6

DESCRIPTION [1381291-36-6]

Overview

MDL	MFCD28385846
Molecular Weight	425.91
Molecular Formula	C23H24ClN3O3
SMILES	O=C1N(CC2(O)CCN(C(CCC3=CC=CC=C3)=O)CC2)C=NC4=C1C=CC(Cl)=C4

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7) , with an IC ₅₀ of 77 μM, and can be used for the research of cancer .

IC50 & Target

IC50: 77 μM (USP7) ^[1]

In Vitro

USP7-IN-1 (Example 2) is a selective and reversible inhibitor of USP7, with an IC ₅₀ of 77 μM, and shows no inhibition of USP8, USP5, Uch-L1, Uch-L3 or caspase 3. USP7-IN-1 inhibits the proliferation of HCT116 cells, with a GI ₅₀ of 67 μM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 234.79 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3479 mL	11.7396 mL	23.4791 mL
5 mM	0.4696 mL	2.3479 mL	4.6958 mL
10 mM	0.2348 mL	1.1740 mL	2.3479 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.87 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.87 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.87 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] SELECTIVE AND REVERSIBLE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7. WO 2013030218 A1