[CAS NO. 1404-19-9] Oligomycin
PRODUCTS SPECIFICATIONS [1404-19-9]
DESCRIPTION [1404-19-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | - |
| Molecular Formula | Unspecified |
| SMILES | [Oligomycin] |
18 Publications Citing Use of MCE
- [1]Mol Cell. 2022 May 19;82(10):1821-1835.e6.
- [2]Nat Commun. 2022 Jun 17;13(1):3486.
- [3]Redox Biol. 2021 Jul;43:101994.
- [4]Cancer Immunol Res. 2023 Jan 23;CIR-22-0531.
- [5]Clin Transl Med. 2022 Jan;12(1):e686.
- [6]Cancer Lett. 2022 Sep 20;215918.
- [7]Cell Death Dis. 2022 Oct 26;13(10):899.
- [8]Cell Death Dis. 2021 Apr 20;12(5):413.
- [9]Free Radic Biol Med. 2023 Feb 8;S0891-5849(23)00055-2.
- [10]Pharmacol Res. 2020 Dec 8;105367.
- [11]Exp Mol Med. 2022 Nov 16.
- [12]Front Immunol. 2022 Mar 10;13:771732.
- [13]Oxid Med Cell Longev. 2022 Apr 5;2022:8192552.
- [14]Cancer Metab. 2022 Dec 6;10(1):22.
- [15]iScience. 4 August 2022, 104844.
- [16]iScience. 21 September 2021.
- [17]Mar Drugs. 2021 Jan 31;19(2):79.
- [18]Immunopharmacol Immunotoxicol. 2022 Dec 8;1-15.
Summary
Oligomycin, an antifungal antibiotic , is an inhibitor of H + -ATP-synthase . Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells [1] [2] [3] [4] .
In Vitro
Oligomycin, inhibitor of the F0 part of H + -ATP-synthase, suppresses the TNF-induced apoptosis [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Streptomyces
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
Ethanol : 30 mg/mL (Need ultrasonic and warming)
DMSO : 20 mg/mL (Need ultrasonic and warming)
References
- [1] Zhou W, et al. Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor. Biochim Biophys Acta Bioenerg. 2018;1859(9):789-796.
- [2] SMITH RM, et al. Oligomycin, a new antifungal antibiotic. Antibiot Chemother (Northfield). 1954;4(9):962-970.
- [3] López de Figueroa P, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976.
- [4] Gong Y, et al. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. Am J Physiol Cell Physiol. 2005;288(5):C1023-C1029.
- [5] Shchepina LA, et al. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene. 2002;21(53):8149-8157.
Synonyms