[CAS NO. 1407966-77-1] PF-06465469

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PRODUCTS SPECIFICATIONS [1407966-77-1]

Catalog

HY-108691

Brand

MCE

CAS

1407966-77-1

MDL	-
Molecular Weight	523.63
Molecular Formula	C30H33N7O2
SMILES	O=C(NC1=CC=C(C(C)C)C(C)=C1)C2=CC=CC(C3=NN([C@H]4CN(C(C=C)=O)CCC4)C5=NC=NC(N)=C53)=C2

For research use only. We do not sell to patients.

PF-06465469 is a covalent inhibitor of ITK with an IC ₅₀ of 2 nM ^[1] .

IC50: 2 nM (ITK) ^[1]

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 11 mg/mL ( 21.01 mM ; Need ultrasonic)

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Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 1.1 mg/mL (2.10 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.1 mg/mL (2.10 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.1 mg/mL (2.10 mM); Clear solution

* All of the co-solvents are available by MCE.