[CAS NO. 14080-23-0] 2-Cyanopyrimidine
PRODUCTS SPECIFICATIONS [14080-23-0]
DESCRIPTION [14080-23-0]
Overview
| MDL | MFCD00160513 |
|---|---|
| Molecular Weight | 105.10 |
| Molecular Formula | C5H3N3 |
| SMILES | N#CC1=NC=CC=N1 |
Summary
2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC 50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos [1] .
IC50 & Target
IC50: 170 nM (cysteine protease cathepsin K) [1]
In Vitro
2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 25 mg/mL ( 237.87 mM ; Need ultrasonic)
DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 9.5147 mL | 47.5737 mL | 95.1475 mL |
| 5 mM | 1.9029 mL | 9.5147 mL | 19.0295 mL |
| 10 mM | 0.9515 mL | 4.7574 mL | 9.5147 mL |
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1.
Add each solvent one by one: PBS
Solubility: 5 mg/mL (47.57 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Synonyms