[CAS NO. 1408064-71-0] JNK-IN-7
PRODUCTS SPECIFICATIONS [1408064-71-0]
DESCRIPTION [1408064-71-0]
Overview
| MDL | MFCD25976765 |
|---|---|
| Molecular Weight | 493.56 |
| Molecular Formula | C28H27N7O2 |
| SMILES | O=C(C1=CC(NC(/C=C/CN(C)C)=O)=CC=C1)NC(C=C2)=CC=C2NC3=NC=CC(C4=CN=CC=C4)=N3 |
3 Publications Citing Use of MCE
Summary
IC50 & Target
|
JNK3 0.7 nM (IC 50 ) |
JNK1 1.5 nM (IC 50 ) |
JNK2 2 nM (IC 50 ) |
In Vitro
JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC 50 =14.1 nM), YSK4 (IC 50 =4.8 nM), ERK3 (IC 50 =22 nM), PIK3C3, PIP5K3 and PIP4K2C [1] . Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 67.53 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0261 mL | 10.1305 mL | 20.2610 mL |
| 5 mM | 0.4052 mL | 2.0261 mL | 4.0522 mL |
| 10 mM | 0.2026 mL | 1.0130 mL | 2.0261 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.75 mg/mL (5.57 mM); Suspended solution; Need ultrasonic
References
- [1] Zhang T, et al. Discovery of Potent and Selective Covalent Inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54.
- [2] Wu W, et al. Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease. Sci Rep. 2015 Nov 17;5:16344.