[CAS NO. 1410101-89-1] (R)-PS210
PRODUCTS SPECIFICATIONS [1410101-89-1]
DESCRIPTION [1410101-89-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 380.31 |
| Molecular Formula | C19H15F3O5 |
| SMILES | O=C(O)C([C@H](C1=CC=CC=C1)CC(C2=CC=C(C(F)(F)F)C=C2)=O)C(O)=O |
Summary
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC 50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment [1] .
IC50 & Target
AC50: 1.8 μM (PDK1) [1]
In Vitro
(R)-PS210 displays an AC 50 value of 1.8 μM towards PDK1 in a Cell-Free Kinase Activity Assay. And the maximum activation of PDK1 compared to DMSO control of (R)-PS210 is 5.5 fold [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 230 mg/mL ( 604.77 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6294 mL | 13.1472 mL | 26.2943 mL |
| 5 mM | 0.5259 mL | 2.6294 mL | 5.2589 mL |
| 10 mM | 0.2629 mL | 1.3147 mL | 2.6294 mL |