[CAS NO. 1418013-75-8] NMS-873

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PRODUCTS SPECIFICATIONS [1418013-75-8]

Catalog

HY-15713

Brand

MCE

CAS

1418013-75-8

DESCRIPTION [1418013-75-8]

Overview

MDL	-
Molecular Weight	520.67
Molecular Formula	C27H28N4O3S2
SMILES	CC(C=C(OCC1=NN=C(SC2CCCC2)N1C3=CC=CN=C3)C=C4)=C4C5=CC=C(S(=O)(C)=O)C=C5

For research use only. We do not sell to patients.

6 Publications Citing Use of MCE

Summary

NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC ₅₀ value of 30 nM.

IC50 & Target

IC50: 30 nM ^[1]

In Vitro

NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC ₅₀ values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC ₅₀ values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC ₅₀ value ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20.5 mg/mL ( 39.37 mM ; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9206 mL	9.6030 mL	19.2060 mL
5 mM	0.3841 mL	1.9206 mL	3.8412 mL
10 mM	0.1921 mL	0.9603 mL	1.9206 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Paola Magnaghi, et al. Covalent and allosteric inhibitors of the ATPATP ase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Jul 28. doi: 10.1038/nchembio.1313.