[CAS NO. 1420071-30-2] Bioymifi
PRODUCTS SPECIFICATIONS [1420071-30-2]
DESCRIPTION [1420071-30-2]
Overview
| MDL | MFCD28118988 |
|---|---|
| Molecular Weight | 494.32 |
| Molecular Formula | C22H12BrN3O4S |
| SMILES | O=C(/C(SC1=N)=C/C2=CC=C(O2)C3=CC(C(N4)=O)=C(C=C3)C4=O)N1C5=CC=C(C=C5)Br |
Summary
In Vitro
Bioymifi (3-10 µM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments
[1]
.
Bioymifi induces apoptosis via death receptor DR5. Bioymifi promotes DR5 aggregation and activation. Bioymifi shares the same DR5-dependent extrinsic apoptotic pathway with TRAIL. Binding of bioymifi to DR5 recruits FADD, which in turn engages with the apical caspase-8 to form death-inducing signaling complex (DISC) Bioymifi (3-10 µM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 12.5 mg/mL ( 25.29 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0230 mL | 10.1149 mL | 20.2298 mL |
| 5 mM | 0.4046 mL | 2.0230 mL | 4.0460 mL |
| 10 mM | 0.2023 mL | 1.0115 mL | 2.0230 mL |
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