[CAS NO. 1422955-31-4] TC-S7009
PRODUCTS SPECIFICATIONS [1422955-31-4]
DESCRIPTION [1422955-31-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 308.65 |
| Molecular Formula | C12H6ClFN4O3 |
| SMILES | ClC1=CC(NC2=C([N+]([O-])=O)C3=NON=C3C=C2)=CC(F)=C1 |
Summary
IC50 & Target
Kd: 81 nM (HIF-2α) [1]
In Vitro
TC-S 7009 (0-100 µM; 72 hours; HPF cells) treatment shows greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions
[2]
.
TC-S 7009 (50 μM) treatment almost completely inhibits the hypoxia-induced NFATc2 nuclear translocation
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [2]
| Cell Line: | HPF cells in hypoxic conditions |
| Concentration: | 0-100 µM |
| Incubation Time: | 72 hours |
| Result: | Showed greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 162.00 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2399 mL | 16.1996 mL | 32.3992 mL |
| 5 mM | 0.6480 mL | 3.2399 mL | 6.4798 mL |
| 10 mM | 0.3240 mL | 1.6200 mL | 3.2399 mL |
-
1.
References