[CAS NO. 1427782-89-5] IWPL6
PRODUCTS SPECIFICATIONS [1427782-89-5]
DESCRIPTION [1427782-89-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 472.58 |
| Molecular Formula | C25H20N4O2S2 |
| SMILES | O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O |
1 Publications Citing Use of MCE
Summary
IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC 50 of 0.5 nM.
IC50 & Target
EC50 Value: 0.5 nM [1]
In Vitro
IWP-L6 (Porcn Inhibitor III) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
IWP-L6 (Porcn Inhibitor III) is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 1.43 mg/mL ( 3.03 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1160 mL | 10.5802 mL | 21.1604 mL |
| 5 mM | --- | --- | --- |
| 10 mM | --- | --- | --- |