[CAS NO. 142796-22-3] Isosilybin B
PRODUCTS SPECIFICATIONS [142796-22-3]
DESCRIPTION [142796-22-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 482.44 |
| Molecular Formula | C25H22O10 |
| SMILES | O=C1[C@H](O)[C@@H](C2=CC=C(O[C@@H](C3=CC=C(O)C(OC)=C3)[C@H](CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15 |
1 Publications Citing Use of MCE
Summary
Isosilybin B, a flavonolignan isolated from Silybum marianum , has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis . Isosilybin B causes androgen receptor (AR) degradation [1] [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.
- [2] Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27(28):3986-98.
Synonyms