[CAS NO. 1429617-90-2] 7rh
PRODUCTS SPECIFICATIONS [1429617-90-2]
DESCRIPTION [1429617-90-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 546.59 |
| Molecular Formula | C30H29F3N6O |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC(CN2CCN(C)CC2)=C1)C3=CC=C(CC)C(C#CC4=CN5C(N=C4)=CC=N5)=C3 |
2 Publications Citing Use of MCE
Summary
7rh (DDR1-IN-2) is a potent inhibitor of discoidin domain receptor 1 ( DDR1 ), with an IC 50 of 13.1 nM, and also less potently inhibits DDR2 , with an IC 50 of 203 nM.
IC50 & Target
IC50: 13.1 nM (DDR1), 203 nM (DDR2), 414 nM (Bcr-Abl), 2500 nM (c-Kit) [1]
In Vitro
7rh (compound 1) is a potent inhibitor of DDR1, with an IC 50 of 13.1 nM, and less potently inhibits DDR2, with an IC 50 of 203 nM. 7rh also shows inhibitory activities against Bcr-Abl and c-Kit, with IC 50 s of 414 and 2500 nM, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 114.35 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8295 mL | 9.1476 mL | 18.2952 mL |
| 5 mM | 0.3659 mL | 1.8295 mL | 3.6590 mL |
| 10 mM | 0.1830 mL | 0.9148 mL | 1.8295 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution