[CAS NO. 143-19-1] Sodium oleate
PRODUCTS SPECIFICATIONS [143-19-1]
DESCRIPTION [143-19-1]
Overview
| MDL | MFCD00004438 |
|---|---|
| Molecular Weight | 304.44 |
| Molecular Formula | C18H33NaO2 |
| SMILES | CCCCCCCC/C=C\CCCCCCCC(O[Na])=O |
11 Publications Citing Use of MCE
- [1]Redox Biol. 15 October 2021, 102168.
- [2]Redox Biol. 2021 Jan;38:101807.
- [3]Cell Rep. 2022 Sep 20;40(12):111381.
- [4]J Exp Clin Cancer Res. 2019 Jul 10;38(1):300.
- [5]Cell Death Dis. 2019 May 28;10(6):416.
- [6]Mol Nutr Food Res. 2022 Nov 25;e2200429.
- [7]Am J Cancer Res. 2020 Apr 1;10(4):1182-1193.
- [8]Oxid Med Cell Longev. 2021 Apr 1.
- [9]Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158540.
- [10]Vet Microbiol. 2021, 109177.
- [11]Biol Pharm Bull. 2022 Feb 3.
Summary
IC50 & Target
Na + /K + ATPase [2]
In Vitro
Oleic acid is the most common monounsaturated fatty acids (FA) in human adipocytes and other tissues. Oleic acid prompts cell proliferation and migration in high metastatic cancer cells via enhancing β-oxidation mediated by AMPK activation. Oleic acid inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01042340 | Karolinska University Hospital|Karolinska Institutet |
Nutritional Intervention
|
December 2005 | Not Applicable |
| NCT03054779 | Penn State University|Canola Council of Canada|University of Manitoba|Laval University|Unity Health Toronto|St. Boniface Hospital |
Cardiovascular Disease|Metabolic Syndrome
|
September 2014 | Not Applicable |
| NCT01661764 | Vanderbilt University|National Cancer Institute (NCI)|Vanderbilt University Medical Center |
Colorectal Adenomatous Polyps
|
February 4, 2013 | Phase 2 |
| NCT01674946 | University Hospital, Basel, Switzerland |
Echolocation
|
September 2011 | Phase 1 |
| NCT03739463 | Université de Sherbrooke|Laval University |
PPROM
|
December 3, 2018 | Not Applicable |
| NCT00535886 | UCSF Benioff Children´s Hospital Oakland|National Cattlemen´s Beef Association |
Cardiovascular Disease|Diabetes|Dyslipidemia
|
November 2005 | Not Applicable |
| NCT01066091 | Yves Boirie|Centre de Recherche en Nutrition Humaine d´Auvergne|ITERG|Institut National de la Recherche Agronomique |
Healthy|Obesity
|
March 2010 | Not Applicable |
| NCT01233778 | Penn State University|University of Manitoba |
Cardiovascular Disease
|
October 2010 | Not Applicable |
| NCT00059254 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|The University of Texas Medical Branch, Galveston |
Obesity|Diabetes|Hyperlipidemia
|
September 2000 | Not Applicable |
| NCT02841618 | Ohio State University |
Healthy Adults
|
January 2016 | Not Applicable |
| NCT04641494 | University of Chester |
Obesity|Lung Functions|Inflammation|Lipid Disorder
|
November 11, 2016 | Not Applicable |
| NCT04997122 | Instituto de Ciencia y Tecnología de Alimentos y Nutrición |
Healthy|Hypercholesterolemia
|
April 2, 2018 | Not Applicable |
| NCT01043445 | Glostrup University Hospital, Copenhagen|University of Copenhagen |
Type 2 Diabetes
|
September 2009 | Not Applicable |
| NCT04531410 | Karolinska Institutet|European Society of Pediatric Gastroenterology, Hepatology and Nutrition |
Cystic Fibrosis
|
October 25, 2021 | Not Applicable |
| NCT01351012 | University of Manitoba|University of Toronto|Penn State University|Laval University |
Metabolic Syndrome
|
September 2010 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 25 mg/mL ( 82.12 mM ; Need ultrasonic)
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2847 mL | 16.4236 mL | 32.8472 mL |
| 5 mM | 0.6569 mL | 3.2847 mL | 6.5694 mL |
| 10 mM | 0.3285 mL | 1.6424 mL | 3.2847 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 9.09 mg/mL (29.86 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
References
- [1] Li S, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330.
- [2] Jack-Hays MG, et al. Activation of Na+/K(+)-ATPase by fatty acids, acylglycerols, and related amphiphiles: structure-activity relationship. Biochim Biophys Acta. 1996 Feb 21;1279(1):43-8.
Synonyms