[CAS NO. 1431525-23-3] BMX-IN-1
PRODUCTS SPECIFICATIONS [1431525-23-3]
DESCRIPTION [1431525-23-3]
Overview
| MDL | MFCD25372042 |
|---|---|
| Molecular Weight | 524.59 |
| Molecular Formula | C29H24N4O4S |
| SMILES | O=C1N(C2=C(C=C1)C=NC3=CC=C(C4=CC=C(NS(=O)(C)=O)C=C4)C=C32)C5=CC=C(C)C(NC(C=C)=O)=C5 |
4 Publications Citing Use of MCE
Summary
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys 496 in the BMX ATP binding domain with an IC 50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC 50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3 , EGFR , Itk , or Tec activity.
IC50 & Target
IC50: 8 nM (BMX), 10.4 nM (BTK)
In Vitro
BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells and RV-1 cells with IC 50 s of 25 nM and 2.53 μM. BMX-IN-1 exhibits remarkable selectivity with an S(10) score of 0.01. BMX-IN-1 inhibits only wild-type BMX with an IC 50 of 138 nM. BMX-IN-1 requires covalent modification of Cys 496 of BMX to achieve potent inhibition [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMF : 10 mg/mL ( 19.06 mM ; Need ultrasonic)
DMSO : 8.33 mg/mL ( 15.88 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9063 mL | 9.5313 mL | 19.0625 mL |
| 5 mM | 0.3813 mL | 1.9063 mL | 3.8125 mL |
| 10 mM | 0.1906 mL | 0.9531 mL | 1.9063 mL |