[CAS NO. 1431945-95-7] FATP1-IN-1
PRODUCTS SPECIFICATIONS [1431945-95-7]
DESCRIPTION [1431945-95-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 375.46 |
| Molecular Formula | C18H22FN5OS |
| SMILES | O=C(NC1=NC(CCCC2)=C2S1)CN3CCN(C4=NC=C(F)C=C4)CC3 |
Summary
FATP1-IN-1 (compound 5k) is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC 50 values of 0.046 μM or 0.60 μM, respectively [1] .
In Vivo
FATP1-IN-1 (p.o.; 10 mg/kg) treatment shows the C max , AUC and T max were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively, and exceeds the mouse IC 50 value of 0.22 μM without considering plasma protein binding.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Mouse plasma [1] |
| Dosage: | 10 mg/kg |
| Administration: | P.o. |
| Result: | The C max , AUC and T max were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 166.46 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6634 mL | 13.3170 mL | 26.6340 mL |
| 5 mM | 0.5327 mL | 2.6634 mL | 5.3268 mL |
| 10 mM | 0.2663 mL | 1.3317 mL | 2.6634 mL |