[CAS NO. 1448460-87-4] Azaphilone-9

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PRODUCTS SPECIFICATIONS [1448460-87-4]

Catalog

HY-124844

Brand

MCE

CAS

1448460-87-4

DESCRIPTION [1448460-87-4]

Overview

MDL	-
Molecular Weight	435.31
Molecular Formula	C21H23BrO5
SMILES	O=C1C(C)(OC(C)=O)C(C2=COC(/C=C/C(C)=C/[C@@H](C)CC)=CC2=C1Br)=O

For research use only. We do not sell to patients.

Summary

Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction ( IC ₅₀ =1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression ^[1] .

IC50 & Target

HuR-ARE ^[1]

In Vitro

Azaphilone-9 is a HuR-RNA inhibitor. However HuR binds and stabilizes the AREs of the oncogene Musashi1 (Msi1) and anti-apoptotic proteins, Bcl2 and XIAP, thereby up-regulating their expression and activating the Wnt/Notch signaling pathway and inhibiting apoptosis ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Kaur K, et al. The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro. PLoS One. 2017 Apr 17;12(4):e0175471.