[CAS NO. 1449236-96-7] NMS-859
PRODUCTS SPECIFICATIONS [1449236-96-7]
DESCRIPTION [1449236-96-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 349.79 |
| Molecular Formula | C15H12ClN3O3S |
| SMILES | O=S1(C2=CC=CC=C2C(NC3=CC(NC(CCl)=O)=CC=C3)=N1)=O |
Summary
NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC 50 s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
IC50 & Target
IC50: 360 nM (Cellular p97, 1 mM ATP), 370 nM (Cellular p97, 60 μM ATP) [1]
In Vitro
NMS-859 is a potent VCP inhibitor, with IC 50 s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. NMS-859 shows very weak inhibitory activity against VCP C522T . NMS-859 also suppresses the proliferation of cells, with IC 50 s of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 142.94 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8589 mL | 14.2943 mL | 28.5886 mL |
| 5 mM | 0.5718 mL | 2.8589 mL | 5.7177 mL |
| 10 mM | 0.2859 mL | 1.4294 mL | 2.8589 mL |
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