[CAS NO. 1454288-88-0]  Rovazolac

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PRODUCTS SPECIFICATIONS [1454288-88-0]

Catalog
HY-109073
Brand
MCE
CAS
1454288-88-0

DESCRIPTION [1454288-88-0]

Overview

MDL-
Molecular Weight452.45
Molecular FormulaC21H19F3N2O4S
SMILESO=C(OCC)CN1C(C2=CC=C(C3=CC(S(C)(=O)=O)=CC=C3)C=C2)=CC(C(F)(F)F)=N1

For research use only. We do not sell to patients.

Summary

Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1.


IC50 & Target

Target: LXR [1]


In Vitro

Rovazolac is an anti-inflammatory drug candidate [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

Ethanol : 25 mg/mL ( 55.25 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2102 mL 11.0509 mL 22.1019 mL
5 mM 0.4420 mL 2.2102 mL 4.4204 mL
10 mM 0.2210 mL 1.1051 mL 2.2102 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% EtOH >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (5.53 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% EtOH >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.53 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

1H-Pyrazole-1-acetic acid, 5-[3′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]-3-(trifluoromethyl)-, ethyl ester
Ethyl 2-[5-[3′-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetate
Rovazolac
ALX 101