[CAS NO. 1454902-97-6] Elevenostat

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PRODUCTS SPECIFICATIONS [1454902-97-6]

Catalog

HY-145757

Brand

MCE

CAS

1454902-97-6

DESCRIPTION [1454902-97-6]

Overview

MDL	-
Molecular Weight	315.32
Molecular Formula	C16H17N3O4
SMILES	O=C(NO)C1=CC=C(CNC(NC2=CC=CC=C2OC)=O)C=C1

For research use only. We do not sell to patients.

Summary

Elevenostat (JB3-22) is a selective HDAC11 inhibitor ( IC ₅₀ =0.235 µM). Anti-multiple myeloma (MM) activity ^[1] .

IC50 & Target

HDAC11

0.235 μM (IC ₅₀ )

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 792.85 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1714 mL	15.8569 mL	31.7138 mL
5 mM	0.6343 mL	3.1714 mL	6.3428 mL
10 mM	0.3171 mL	1.5857 mL	3.1714 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.60 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (6.60 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.60 mM); Clear solution

* All of the co-solvents are available by MCE.