[CAS NO. 1467047-25-1] SRS11-92

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1467047-25-1]

Catalog

HY-116087

Brand

MCE

CAS

1467047-25-1

DESCRIPTION [1467047-25-1]

Overview

MDL	-
Molecular Weight	352.47
Molecular Formula	C22H28N2O2
SMILES	O=C(C1=CC=C(NC2CCCCC2)C(NCC3=CC=CC=C3)=C1)OCC

For research use only. We do not sell to patients.

Summary

SRS11-92, a Ferrostatin-1 (Fer-1) analogue, is a potent ferroptosis inhibitor. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells (EC ₅₀ =6 nM) ^[1] .

In Vitro

SRS11-92 fully protects oligodendrocytes (OLs) from cystine deprivation when tested at 100 nM. SRS11-92 rescues primary human fibroblasts from death induced by frataxin knock-down ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRS11-92, used at 500 nM, is efficacious in protecting human and mouse cellular models of Friedreich ataxia (FRDA) treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO), whereas caspase-3 inhibitors fail to show significant biological activity ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Powder

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 709.28 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8371 mL	14.1856 mL	28.3712 mL
5 mM	0.5674 mL	2.8371 mL	5.6742 mL
10 mM	0.2837 mL	1.4186 mL	2.8371 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (5.90 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.90 mM); Clear solution

* All of the co-solvents are available by MCE.