[CAS NO. 147127-19-3] (S)-Tenofovir

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PRODUCTS SPECIFICATIONS [147127-19-3]

Catalog

HY-W074930

Brand

MCE

CAS

147127-19-3

DESCRIPTION [147127-19-3]

Overview

MDL	MFCD21604708
Molecular Weight	287.21
Molecular Formula	C9H14N5O4P
SMILES	OP(O)(CO[C@@H](C)CN1C=NC2=C(N)N=CN=C12)=O

For research use only. We do not sell to patients.

Summary

(S)-Tenofovir ((S)-GS 1278) is the less active S-enantiomer of Tenofovir. Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL ( 17.41 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4818 mL	17.4089 mL	34.8177 mL
5 mM	0.6964 mL	3.4818 mL	6.9635 mL
10 mM	0.3482 mL	1.7409 mL	3.4818 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.5 mg/mL (1.74 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.5 mg/mL (1.74 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.5 mg/mL (1.74 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3).