[CAS NO. 147591-46-6] ID-8

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PRODUCTS SPECIFICATIONS [147591-46-6]

Catalog

HY-15838

Brand

MCE

CAS

147591-46-6

DESCRIPTION [147591-46-6]

Overview

MDL	MFCD00593367
Molecular Weight	298.29
Molecular Formula	C16H14N2O4
SMILES	OC1=CC2=C(C=C1)C([N+]([O-])=O)=C(C)N2C3=CC=C(OC)C=C3

For research use only. We do not sell to patients.

4 Publications Citing Use of MCE

Summary

ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) . ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs ^[1] ^[2] .

IC50 & Target

DYRK ^[1]

In Vitro

ID-8 (0.1-10 μM) increases human embryonic stem cell (hESC) survival ^[1] .
ID-8 (10 μM) stimulates ESCs proliferation in serum-free media for more than 1 month ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 47 mg/mL ( 157.56 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3524 mL	16.7622 mL	33.5244 mL
5 mM	0.6705 mL	3.3524 mL	6.7049 mL
10 mM	0.3352 mL	1.6762 mL	3.3524 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (8.38 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.