[CAS NO. 1482500-76-4] ML-290
PRODUCTS SPECIFICATIONS [1482500-76-4]
DESCRIPTION [1482500-76-4]
Overview
| MDL | MFCD28118984 |
|---|---|
| Molecular Weight | 506.49 |
| Molecular Formula | C24H21F3N2O5S |
| SMILES | O=C(NC1=CC(S(=O)(C(F)(F)F)=O)=CC=C1)C2=C(NC(C3=CC=CC=C3OC(C)C)=O)C=CC=C2 |
Summary
ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor ( RXFP1 ) agonist and activator of anti-fibrotic genes, with an EC 50 of 94 nM [1] . ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.
IC50 & Target
EC50: 94 nM (RXFP1) [1]
In Vitro
ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC
50
of 94 nM
[1]
.
ML290 (5 μM) shows anti-fibrotic, relaxin-like gene expression at 24 and 72 h in activated human hepatic stellate cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 246.80 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9744 mL | 9.8719 mL | 19.7437 mL |
| 5 mM | 0.3949 mL | 1.9744 mL | 3.9487 mL |
| 10 mM | 0.1974 mL | 0.9872 mL | 1.9744 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution