[CAS NO. 1515887-44-1] UCB-5307
PRODUCTS SPECIFICATIONS [1515887-44-1]
DESCRIPTION [1515887-44-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 343.42 |
| Molecular Formula | C22H21N3O |
| SMILES | OC(C1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2)C4=CC=NC=C4 |
Summary
UCB-5307 is a potent TNF signaling inhibitor with a K D of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex [1] .
In Vitro
UCB-5307 inhibits wild-type TNF but does not inhibit L57F TNF. The T
1/2
of UCB-5307 is 3.3 h
[1]
.
UCB-5307 disrupts a preformed hTNF/hTNFR1 complex, can penetrate the preformed complex, dislodging one of the receptors. Preloading hTNF with UCB-5307 blocks one receptor from binding
[1]
.
UCB-5307 binds to a pocket in the centre of the TNF trimer formed by the movement of the TNF monomers, stabilising the distorted trimer, which leads to reduced signalling through TNFR1
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 50 mg/mL ( 145.59 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9119 mL | 14.5594 mL | 29.1189 mL |
| 5 mM | 0.5824 mL | 2.9119 mL | 5.8238 mL |
| 10 mM | 0.2912 mL | 1.4559 mL | 2.9119 mL |