[CAS NO. 152755-31-2] LY 295427

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PRODUCTS SPECIFICATIONS [152755-31-2]

Catalog

HY-125544

Brand

MCE

CAS

152755-31-2

DESCRIPTION [152755-31-2]

Overview

MDL	-
Molecular Weight	428.73
Molecular Formula	C30H52O
SMILES	CC(CCC[C@H]([C@H]1CC[C@]2([C@@]3(CC[C@]4([C@@H]([C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)CC=C)[H])[H])[H])C)C

For research use only. We do not sell to patients.

Summary

LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research ^[1] ^[2] ^[3] .

In Vitro

LY 295427 time-dependently increases the uptake of 25-OH chol in Chinese hamster ovary (CHO) cells ^[1] .
LY 295427 (2.9 μM) increases 30% LDL receptor promoter activity ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LY 295427 dose-dependently decreases cholesterol by derepressing LDL-R transcription in cholesterol-coconut oil-fed hamsters with a ED ₅₀ value of 40 mg/kg/day ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.