[CAS NO. 153355-70-5] Ginkgolide K

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PRODUCTS SPECIFICATIONS [153355-70-5]

Catalog

HY-N4176

Brand

MCE

CAS

153355-70-5

DESCRIPTION [153355-70-5]

Overview

MDL	-
Molecular Weight	406.38
Molecular Formula	C20H22O9
SMILES	O[C@@H]([C@]1([H])O2)C34C5([C@H]6O)[C@](OC6=O)([H])O[C@@]3(C(O[C@]4([H])C[C@H]5C(C)(C)C)=O)C1=C(C)C2=O

For research use only. We do not sell to patients.

Summary

Ginkgolide K, isolated from Ginkgo biloba , induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 123.04 mM ; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4608 mL	12.3038 mL	24.6075 mL
5 mM	0.4922 mL	2.4608 mL	4.9215 mL
10 mM	0.2461 mL	1.2304 mL	2.4608 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Zhang Y, et al. Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Eur J Pharmacol. 2018 Aug 5;832:96-103.