[CAS NO. 1542213-00-2] NCT-502
PRODUCTS SPECIFICATIONS [1542213-00-2]
DESCRIPTION [1542213-00-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 395.45 |
| Molecular Formula | C18H20F3N5S |
| SMILES | S=C(NC1=NC(C)=CC(C)=C1)N2CCN(CC2)C3=NC=C(C=C3)C(F)(F)F |
4 Publications Citing Use of MCE
Summary
NCT-502 is a human phosphoglycerate dehydrogenase ( PHGDH ) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC 50 of 3.7 μM against PHGDH [1] .
IC50 & Target
IC50: 3.7 μM (PHGDH) [1]
In Vitro
NCT-502 is cytotoxic to MDA-MB-468, with an EC 50 of 15.2 µM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 130 mg/mL ( 328.74 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5288 mL | 12.6438 mL | 25.2876 mL |
| 5 mM | 0.5058 mL | 2.5288 mL | 5.0575 mL |
| 10 mM | 0.2529 mL | 1.2644 mL | 2.5288 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.17 mg/mL (5.49 mM); Clear solution