[CAS NO. 154447-35-5] NU7026

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PRODUCTS SPECIFICATIONS [154447-35-5]

Catalog

HY-15719

Brand

MCE

CAS

154447-35-5

DESCRIPTION [154447-35-5]

Overview

MDL	MFCD06798345
Molecular Weight	281.31
Molecular Formula	C17H15NO3
SMILES	O=C1C2=CC=C3C=CC=CC3=C2OC(N4CCOCC4)=C1

For research use only. We do not sell to patients.

11 Publications Citing Use of MCE

Summary

NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC ₅₀ of 0.23 μM, also inhibits PI3K with IC ₅₀ of 13 μM.

IC50 & Target

DNA-PK

0.23 μM (IC ₅₀ )

PI3K

13 μM (IC ₅₀ )

In Vitro

NU7026 (10 μM) potentiates ionizing radiation (IR) cytotoxicity [potentiation factor at 90% cell kill (PF ₉₀ )=1.51±0.04] in exponentially growing DNA-PK proficient but not deficient cells ^[1] . NU7026 synergistically sensitizes I83 cells to Chlorambucil (CLB) 3.5-fold ^[2] .NU7026, a novel inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). At a dose of 10 μM, which is nontoxic to cells per se , a minimum NU7026 exposure of 4 h in combination with 3 Gy radiation is required for a significant radiosensitisation effect in CH1 human ovarian cancer cells ^[3] .
Solution in vitro : NU7026 is dissolved in anhydrous DMSO. NU7026 is added to cells to a final concentration of 0.25% DMSO (v/v) ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NU7026, a novel inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). Following intravenous administration to mice at 5 mg/kg, NU7026 underwent rapid plasma clearance (0.108 L/h) and this is largely attributed to extensive metabolism. Bioavailability following interperitoneal (i.p.) and p.o. administration at 20 mg/kg is 20 and 15%, respectively ^[3] .
Solution in vivo:
NU7026 is formulated in 10% DMSO and 5% Tween 20 in saline (i.p. and p.o.) (Mice) ^[3] .
NU7026 is formulated in 10% ethanol, 25% PEG 200 and 5% Tween 20 in saline (i.v.) ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 2.5 mg/mL ( 8.89 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5548 mL	17.7740 mL	35.5480 mL
5 mM	0.7110 mL	3.5548 mL	7.1096 mL
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

4H-Naphtho[1,2-b]pyran-4-one, 2-(4-morpholinyl)-

2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one

LY 293646

NU 7026

2-Morpholin-4-ylbenzo[h]chromen-4-one