[CAS NO. 154566-12-8] SB204990

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PRODUCTS SPECIFICATIONS [154566-12-8]

Catalog

HY-16450

Brand

MCE

CAS

154566-12-8

DESCRIPTION [154566-12-8]

Overview

MDL	-
Molecular Weight	389.27
Molecular Formula	C18H22Cl2O5
SMILES	O=C(O)C[C@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

For research use only. We do not sell to patients.

5 Publications Citing Use of MCE

Summary

SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

IC50 & Target

ACLY ^[1] .

In Vitro

SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 256.89 mM )

H ₂ O : 25 mg/mL ( 64.22 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5689 mL	12.8446 mL	25.6891 mL
5 mM	0.5138 mL	2.5689 mL	5.1378 mL
10 mM	0.2569 mL	1.2845 mL	2.5689 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 2.56 mg/mL (6.58 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution

* All of the co-solvents are available by MCE.