[CAS NO. 1557232-32-2] GNE-9822
PRODUCTS SPECIFICATIONS [1557232-32-2]
DESCRIPTION [1557232-32-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 420.55 |
| Molecular Formula | C24H32N6O |
| SMILES | CN(C)CC[C@H](N1N=CC(NC(C2=NNC3=C2CCC(C)(C)C3)=O)=C1)C4=CC=CC=C4 |
Summary
In Vitro
GNE-9822 (compound 28) inhibits the phosphorylation of PLCγ with an IC 50 value of 55 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
GNE-9822 (compound 28; po and iv; 1 and 5 mg/kg) has good bioavailability and halflives observed in mouse and rats [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | BALB/c mouse and Sprague-Dawley rats [1] | ||||||||||||||||||||||||||||||
| Dosage: | 1 and 5 mg/kg | ||||||||||||||||||||||||||||||
| Administration: | po (5 mg/kg) and iv (1 mg/kg) | ||||||||||||||||||||||||||||||
| Result: |
|
| Animal Model: | BALB/c mouse and Sprague-Dawley rats [1] | ||||||||||||||||||||||||||||||
| Dosage: | 1 and 5 mg/kg | ||||||||||||||||||||||||||||||
| Administration: | po (5 mg/kg) and iv (1 mg/kg) | ||||||||||||||||||||||||||||||
| Result: |
|
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 148.61 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3778 mL | 11.8892 mL | 23.7784 mL |
| 5 mM | 0.4756 mL | 2.3778 mL | 4.7557 mL |
| 10 mM | 0.2378 mL | 1.1889 mL | 2.3778 mL |