[CAS NO. 1558598-41-6] PFM01

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PRODUCTS SPECIFICATIONS [1558598-41-6]

Catalog

HY-116770

Brand

MCE

CAS

1558598-41-6

DESCRIPTION [1558598-41-6]

Overview

MDL	MFCD02220972
Molecular Weight	293.40
Molecular Formula	C14H15NO2S2
SMILES	O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S

For research use only. We do not sell to patients.

Summary

PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) ^[1] ^[2] .

IC50 & Target

Endonuclease ^[1]

In Vitro

PFM01 (100 μM) rescues the repair defect in 48BR (WT) and HSC62 (BRCA2-defective) primary cells ^[1] .
PFM01 (100 μM) diminishes the RAD51 foci formation in 1BR3 (WT) and HSC62 (BRCA2-defective) cells ^[1] .
PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells ^[1] .
PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 340.83 mM )

Ethanol : 25 mg/mL ( 85.21 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4083 mL	17.0416 mL	34.0832 mL
5 mM	0.6817 mL	3.4083 mL	6.8166 mL
10 mM	0.3408 mL	1.7042 mL	3.4083 mL

* Please refer to the solubility information to select the appropriate solvent.