[CAS NO. 1558598-48-3] PFM03
PRODUCTS SPECIFICATIONS [1558598-48-3]
DESCRIPTION [1558598-48-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 293.40 |
| Molecular Formula | C14H15NO2S2 |
| SMILES | OC1=CC=C(/C=C2C(N(C(C)CC)C(S/2)=S)=O)C=C1 |
Summary
PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) [1] .
In Vitro
PFM03 (50-400 μM; 30 min) specifically inhibits MRE11 endonuclease activity
[1]
.
PFM03 (100 μM; 30 min) causes normal DSB repair in G2 (CENPF
+
) cells
[1]
.
PFM03 (50 μM; 8 h) enhances NHEJ usage but reduces homologous recombination (HR) in cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.