[CAS NO. 156-38-7] 4-Hydroxyphenylacetic acid
PRODUCTS SPECIFICATIONS [156-38-7]
DESCRIPTION [156-38-7]
Overview
| MDL | MFCD00004347 |
|---|---|
| Molecular Weight | 152.15 |
| Molecular Formula | C8H8O3 |
| SMILES | O=C(O)CC1=CC=C(O)C=C1 |
Summary
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols , is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 [1] .
IC50 & Target
|
Human Endogenous Metabolite |
Microbial Metabolite |
In Vivo
4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 657.25 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.5725 mL | 32.8623 mL | 65.7246 mL |
| 5 mM | 1.3145 mL | 6.5725 mL | 13.1449 mL |
| 10 mM | 0.6572 mL | 3.2862 mL | 6.5725 mL |
Synonyms