[CAS NO. 158959-32-1] SC57666
PRODUCTS SPECIFICATIONS [158959-32-1]
DESCRIPTION [158959-32-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 316.39 |
| Molecular Formula | C18H17FO2S |
| SMILES | O=S(C1=CC=C(C2=C(C3=CC=C(F)C=C3)CCC2)C=C1)(C)=O |
Summary
SC57666 is a selective COX2 inhibitor with an IC 50 of 26 nM.
IC50 & Target
|
COX-2 26 nM (IC 50 ) |
In Vitro
SC57666 inhibits COX2 with an IC 50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC 50 =6000±1900 nM) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
SC57666 has been shown to be orally active (ED 50 =1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 316.07 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1607 mL | 15.8033 mL | 31.6066 mL |
| 5 mM | 0.6321 mL | 3.1607 mL | 6.3213 mL |
| 10 mM | 0.3161 mL | 1.5803 mL | 3.1607 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.90 mM); Clear solution
References
- [1] Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81.
- [2] Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.